Warner Bros. Pictures has released the brand new trailer for the upcoming tentpole Rampage, which stars Dwayne Johnson and Naomi Harris.

Primatologist Davis Okoye (Johnson), a man who keeps people at a distance, shares an unshakable bond with George, the extraordinarily intelligent, silverback gorilla who has been in his care since birth. But a rogue genetic experiment gone awry mutates this gentle ape into a raging creature of enormous size. To make matters worse, it’s soon discovered there are other similarly altered animals. As these newly created alpha predators tear across North America, destroying everything in their path, Okoye teams with a discredited genetic engineer to secure an antidote, fighting his way through an ever-changing battlefield, not only to halt a global catastrophe but to save the fearsome creature that was once his friend.

Rampage also stars also stars Malin Akerman, Jake Lacy, Joe Manganiello and Jeffrey Dean Morgan, as well as P.J. Byrne, Marley Shelton, Breanne Hill, Jack Quaid, and Matt Gerald.

Watch the brand new trailer for the film below. Rampage opens on April 13th.